I summed factors to produce the complete mineral eating plan score, which varied out-of step 3 in order to 15
To look at relationships ranging from diet and coronary arrest, i put Cox proportional potential risks models stratified because of the years (mo) and you may follow-up duration to guess RRs and you will 95% CIs. Users was in fact divided into quintiles out-of cumulative average intake out-of magnesium, potassium, and you may calcium supplements to reduce the within-people type and greatest portray much time-title intake ( 18). A mixed nutrient eating plan get out-of magnesium, potassium, and you will calcium was indeed determined by assigning factors to for every quintile and you may summing this new affairs. Participants from the low quintile (quintile step one) away from magnesium, potassium, otherwise calcium consumption gotten 1 part for each and every mineral, members in the next quintile (quintile dos) gotten dos activities, an such like. Collective averages was in fact computed if you take the imply of all said FFQ consumption to the beginning of for each dos-y pursue-up period. The new cumulative average consumption was utilized to predict coronary arrest frequency out-of committed of your own last came back questionnaire through to the next go after-right up years.
Multivariate models have been modified having years (mo) and diary time (2-y time menstruation) and you will included consumption away from total time (kcal), alcohol (g/d), cig, Bmi, physical activity, parental reputation of very early myocardial infarction, postmenopausal hormones cures use, thiazide explore, aspirin play with, multi vitamin play with, and you will reputation for diabetes, hypertension, and you will hypercholesterolemia during the standard. To check to own good linear pattern, i tasked for every quintile this new average worth and you can modeled so it changeable once the a continuing changeable. I tested the possibility deviation out-of linearity by using an odds proportion decide to try to possess testing from an unit toward linear term that have a design including the linear name and additionally minimal cubic spline transformations ( 19). I including used analyses you to incorporated most of the step three vitamins likewise. Magnesium and you can potassium consumption had been highly correlated (roentgen = 0.79 regarding NHS We; r = 0.73 regarding NHS II), and you may correlations ranging from calcium supplements and you may potassium intakes (roentgen = 0.forty-two about NHS I; roentgen = 0.41 regarding NHS II), while between calcium supplements and you can magnesium consumption (roentgen = 0.54 regarding the NHS We; roentgen = 0.56 in the NHS II) was average. This new Q test was used to evaluate into heterogeneity between the fresh new NHS I and you can NHS II. RRs (±SEs) for every single quintile away from for each cohort was pooled for the repaired-effects models to assess realization rates ( 20). Similarly, the newest up-to-date meta-analysis then followed fundamental practice ( 20) from review having heterogeneity with the Q make sure having fun with fixed consequences design to manufacture summary rates whenever zero between-training heterogeneity is clear; if you don’t a haphazard-outcomes design was used.
To examine the potential effect modification of the association between dietary minerals and stroke risk by age, hypertension, and diabetes, we stratified our multivariate model on age (<60 compared with ?60 y), hypertension (yes compared with no), and diabetes (yes compared with no) and separately tested the significance of an interaction by using a likelihood ratio test for the comparison of the model with interaction terms to the model with only main effects. All P values were 2-sided, and analyses were conducted with SAS 9.2 software (SAS Institute Inc.).
Through the 31 y regarding follow-up regarding 1980 because of 2010 on NHS I and you may twenty two y out of realize-up off 1989 courtesy 2011 on NHS II, all in all, 3780 event coronary attack instances was ascertained. Of those cases, 3237 incident strokes was indeed documented from the NHS I (and 1664 ischemic, 544 hemorrhagic, and you may 1029 unspecified shots), and 543 experience shots was basically documented on the NHS II (plus 186 ischemic, 92 hemorrhagic, and you will 265 unspecified strokes). Age-standard characteristics away from research users at the midpoint throughout the realize-upwards into the 1994 for the NHS I along with 1995 getting this new NHS II receive during the Table step one. Female with highest nutrient intake had been expected to play with aspirin, vitamins, and postmenopausal hormonal cures, even more yourself active, less inclined to end up being newest smokers than just had been women that have all the way down nutrient intake Military Sites dating app. Data for women throughout the NHS We and NHS II was basically shared once the we did not observe a life threatening anywhere between-research heterogeneity (Q-statistic P > 0.05).